A numerical study of the aerosol behavior in intra-acinar region of a human lung.

Abstract

The determination of the particle dynamics in the human acinar airways having millions of alveoli is critical in preventing potential health problems and delivering therapeutic particles effectively to target locations. Despite its complex geometrical structure and complicate wall movements, the advanced calculation simulations can provide valuable results to accurately predict the aerosol deposition in this region. The objective of this study was to numerically investigate the aerosol particle transport and deposition in the intra-acinar region of a human lung for different breathing scenarios (i.e., light, normal, and heavy activities) during multiple breaths. Idealized intra-acinar models utilized in this study consisted of a respiratory bronchial model, an alveolar duct model, and an alveolar sac model. The particles with 5 μm in diameter released from the inlet of the model were tracked until they deposited or escaped from the computational domain. The results showed that due to the rhythmic alveolar wall movement, the flow field was divided into two regions: one is the low-speed alveolar flow and the other is the channel flow. It was found that the chaotic acinar flow irreversibility played a significant role in the aerosol transport in higher generations. During the succeeding breaths, more particles deposited or escaped to the relating acinar generation and reached the more distal regions of the lung. The number of particles remaining in the suspension at the end of the third cycle ranged from 0.016% to 3%. When the mouth flow rate increased, the number of particles remaining in the suspension reduced, resulting in higher deposition efficiency. The total deposition efficiencies for each flow rate were 24%, 47%, and 77%, respectively. The particle simulation results also showed that more breathing cycle was required for full aerosol particle deposition or escape from the model. In addition to the alveolar wall motion, the type of breathing condition and breathing cycle had a significant effect on the accurate prediction of the aerosol deposition in the intra-acinar region of the human lung.