Abstract
Heterogeneities of ionic current expression and electrophysiological characteristics exist within the mammalian ventricle wall and are assumed to be the result of regional differences in myocardial membrane ionic current densities. This work describes computational approaches of modeling the cardiac cellular excitability and electrical activity propagation in the spatially inhomogeneous ventricular tissue. A three-dimensional (3D) unsteady Rogers model with one gating variable has been considered for simulating the cardiac electrical activity. Based on the paradigm of domain decomposition a 3D finite element scheme has been developed and implemented using PETSc Library under MPI environment. The numerical simulations are carried out on IBM SP3 machine. The computational studies provide insight into the underlying mechanisms during the normal and pathological cardiac excitation.
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