Abstract
The aim of this study is to investigate the variation of the blood perfusion rate and distribution of oxygen partial pressure ( PO 2 ) in human tumors by a coupling numerical model when laser irradiation is used as an adjuvant method in the treatment of cancer. A two-dimensional finite element (FE) thermal model of a human breast with a tumor was developed. The blood circulation inside the breast was modeled using one-dimensional non-linear equations of pulsatile fluid flow. The distribution of PO 2 inside the capillaries, tumor vessels, and surrounding tissue was obtained by the Krogh analysis model. Finally, the variations of the average tumor temperature, blood perfusion, and PO 2 during laser heating were computed by coupling the blood circulation, FE thermal, and oxygen transport models.
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