Abstract
An Mg 2+-dependent endonuclease endogenous to rat-liver nuclei had an exonuclease activity for single-stranded DNA, but not for duplex DNA. The activity was about twice as high in the 3′ → 5′ direction as in the 5′ → 3′ direction. The products by 3′ → 5′ activity were mononucleotides alone. The 5′ → 3′ activity released mononucleotides as main products and small amounts of di-, tri-, tetra- and oligonucleotides. Another major endonuclease endogenous to the nuclei, a Ca 2+/Mg 2+-dependent endonuclease, did not have such exonuclease activities.
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