Abstract
ZrO2-nanotubes, demonstrating good mechanical characteristics and corrosion resistance, however, cell biocompatibility and Streptococcus mutans adhesive capacity haven't been evaluated. This study aimed to evaluate biocompatibility, adhesion to Streptococcus mutans, safety of ZrO2-nanotubes. In this study, proliferation of ZrO2-nanotubes treated cells was determined. Adhesive capacity to cell and safety of ZrO2-nanotubes were evaluated with transmission electron microscopy (TEM) and HE staining/chromosome aberration assay, respectively. Growth of Streptococcus mutans, live/dead bacteria on ZrO2-nanotubes and adhesive capacity to Streptococcus mutans of ZrO2-nanotubes were also evaluated. ZrO2-nanotubes were successfully synthesized exhibiting appropriate monoclinic phase intensity, without obvious transistor-structure and effects on proliferation. More L929 colonies adhered to ZrO2-nanotubes, however, only a few adhered to ZrO2 control. ZrO2-nanotubes didn't induce inflammatory effect on rats' cheek pouch and chromosome aberration of rat bone marrow, and was proven to be safe for important organs. ZrO2-nanotubes inhibited growth, induced dead of Streptococcus mutans, and obviously repelled adhesion of Streptococcus mutans. In conclusion, this study generated a novel and safe implant, ZrO2-nanotube. ZrO2-nanotube could induce Streptococci mutans dead, demonstrating higher cell biocompatibility and lower Streptococci mutans adhesive capacity and apply in treatment of dental caries.
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