Abstract
A novel, lamellar type Vanadium n-propylamino phosphate catalyst is synthesized and characterized by using various physicochemical techniques such as Powder X-ray diffraction, Scanning electron microscopy/Energy dispersive X-ray analysis, Thermogravimetry/Differential thermal analysis, Fourier transform Infrared analysis, Electron spin resonance spectroscopy, Ultraviolet - Visible Diffuse reflectance spectroscopy, X-ray Photoelectron spectroscopy, 31P Magic angle spinning Nuclear Magnetic Resonance spectroscopy and Catalytic applications toward Octahydroquinazolinone synthesis. It is found that the n-propylamine is present as sandwich between Vanadyl phosphate layers. Most of the Vanadium is present as V4+ ions in tetrahedral co-ordination. Vanadium n-propylamino phosphate catalyses Octahydroquinazolinone synthesis more effeciently and the optimum conditions required for Octahydroquinazolinone synthesis are, Benzaldehyde (2 mmol), Dimedone (2 mmol), Urea (4 mmol), Methanol + Water (1:1, 5 mL) and Catalyst (0.05 g). A plausible mechanism is also proposed.
Highlights
The Octahydroquinazolinones derivatives have attracted considerable attention, as they exhibit potent antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa[1], and calcium antagonist activity[2,3].In 1893, Italian chemist Pietro Biginelli was first reported, the acid catalyzed cyclocondensation reaction of an aldehyde, ethylacetoacetate and urea
The peaks at 21.1° and 26.2° values indicates the presence of Vanadium ions[29] predominantly in V4+ state with small amount in V5+[30] and peak at 19.0° indicates the presence of Vanadium phosphate[31] layer
The peaks at 13.9°, 19°, 22°, 24° and 26.2° are due to the presence of VOPO4 phases[32] in Vanadium n-propylamino phosphate
Summary
The Octahydroquinazolinones derivatives have attracted considerable attention, as they exhibit potent antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa[1], and calcium antagonist activity[2,3]. In 1893, Italian chemist Pietro Biginelli was first reported, the acid catalyzed cyclocondensation reaction of an aldehyde, ethylacetoacetate and urea. The Biginelli reaction has been found to employ in the synthesis of Octahydroquinazolinones, which involves Knoevenagel condensation, Michael addition and cyclization of aromatic aldehydes, urea and cyclic β-diketones[4]. Literature survey reveals a number of homogeneous and heterogeneous catalytic systems used for synthesis of octahydroquinazolinone derivatives which includes TMSCl5, conc.
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