Abstract
Simulated i.v. infusions of perilla ketone, a highly lipophilic investigational cytotoxic agent, in 5% dextrose injection (D5W) through various types of i.v. administration sets resulted in considerable loss of the drug due to uptake by the plastic. Ipomeanol, a structurally similar cytotoxic agent with reduced lipophilicity, where a methyl group was replaced by a hydroxyl group, was not subject to uptake as predicted by the differences in the partitioning behavior of the two compounds. Uptake of perilla ketone by Polyvinylchloride -based sets was much greater than by polyethylene- or polyolefine-based sets. This phenomenon was completely prevented by incorporating perilla ketone into a commercially available fat emulsion, Intralipid.
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