Abstract

AbstractA novel derivative of urocanic acid (1) had been isolated from acetone extracts of rabbit skin tissue. It proved to be (E)‐3‐[1‐(1,1‐dimethyl‐3‐oxobutyl)imidazol‐4‐yl]propenoic acid (3c), potentially a much better ultraviolet screening agent than urocanic acid. Sterical effect of dimethyl groups in the side chain adjacent to the imidazole ring of 3c on its solubility is also discussed.

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