A novel type of cosavirus from children with nonpolio acute flaccid paralysis.

Yan Yang,Xiaofen Xu,Xinyu Cao,Ying Tao,Aiping Ju

doi:10.1186/s12985-016-0630-3

Abstract

Human cosavirus (HCoSV) is a genus recently identified in the family Picornaviridae, which contains important pathogens to human health. Here, a novel type of HCoSV strain, cosavirus-zj-1 (GenBank no. KX545380), was identified in the fecal sample of a child with nonpolio acute flaccid paralysis (AFP) in China. Phylogenetic and sequence analyses suggested that this virus strain belonged to a new genotype in HCoSV B species. Our data show that surveillance of HCoSV is necessary for detecting viral agents in children with AFP, despite being the low detection rate.

Highlights

Human cosavirus (HCoSV) is a genus recently identified in the family Picornaviridae, which contains important pathogens to human health
Human Cosavirus (HCoSV) is a new member in the Picornaviridae family. It was originally detected from fecal samples of both healthy children and non-polio acute flaccid paralysis (AFP) patients in Pakistan and Afghanistan as well as in a fecal sample of a 64-year- old woman from Scotland [1, 2]
The genome of HCoSV is about 7.6 kb long organized in a typical picornavirus genome, the only difference is the absence of the leader (L) sequence [1]

Summary

Introduction

Human cosavirus (HCoSV) is a genus recently identified in the family Picornaviridae, which contains important pathogens to human health. A total of 29 fecal samples were collected from 29 children between January 2010 and December 2014 with clinical manifestations of AFP but no detection of poliovirus. In order to get the full genome of this divergent HCoSV strain and investigate whether this fecal sample contain other viral pathogens, viral metagenomic method was used to detect the viral nucleic acid in this sample as previously reported [11].

Results

Conclusion