A novel treatment strategy to decrease OHSS across all stimulation protocols

Abstract

As we attempt to optimize outcomes in in vitro fertilization (IVF), it is important to determine how to diminish the risk of ovarian hyperstimulation syndrome (OHSS). Strategies used in high risk patients include coasting, gonadotropin releasing hormone (GnRH) agonist trigger, or a lower dose of human chorionic gonadotropin (hCG). Previous studies have attempted to find the lowest effective dose of hCG that adequately promotes oocyte maturation in an effort to decrease the risk of OHSS, which is especially important in down-regulated cycles where GnRH agonist trigger is not an option.