Abstract
Background Arterial stiffness is one of the most potent prognostic factors of cardiovascular morbidity and mortality. Its surrogate parameter, pulse wave velocity (PWV), is most commonly assessed by carotid-femoral applanation tonometry (AT). Limited availability of the AT equipment limits its application in clinical practice. Phase contrast cardiac magnetic resonance (CMR) offers insight in arterial stiffness at no extra cost, without significant protocol extension. As CMR accessibility increases, validated post-processing tools for CMRderived PWV measurement are needed. The aim of the study was to provide a validated, freely available tool to measure PWV using a routine CMR protocol.
Highlights
Arterial stiffness is one of the most potent prognostic factors of cardiovascular morbidity and mortality
applanation tonometry (AT)- and cardiac magnetic resonance (CMR)-derived pulse wave velocity (PWV) measurements were compared in 21 subjects (10 healthy subjects aged 28±8 (1644) yrs in whom cardiovascular disease was excluded based on clinical assessment and CMR result and 11 patients with hyperlipidemia and/or hypertension aged 57,8 ± 7,5 yrs)
For CMRPWV there were overlap with one patients compared to normals, whereas there was an overlap with three patients for AT-PWV (Figure 1, right panel)
Summary
Arterial stiffness is one of the most potent prognostic factors of cardiovascular morbidity and mortality. Pulse wave velocity (PWV), is most commonly assessed by carotid-femoral applanation tonometry (AT). Limited availability of the AT equipment limits its application in clinical practice. Phase contrast cardiac magnetic resonance (CMR) offers insight in arterial stiffness at no extra cost, without significant protocol extension. As CMR accessibility increases, validated post-processing tools for CMRderived PWV measurement are needed. The aim of the study was to provide a validated, freely available tool to measure PWV using a routine CMR protocol
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