A NOVEL TGD® DEVICE TO GENERATE THERAPEUTIC PLATELET GLUE

Abstract

Biomedical Engineering: Applications, Basis and CommunicationsVol. 19, No. 04, pp. 225-229 (2007) No AccessA NOVEL TGD® DEVICE TO GENERATE THERAPEUTIC PLATELET GLUEJui-Che Tsai, Shyh Ming Kuo, Shwu Jen Chang, Ioannis Manousakas, and Tim-Mo ChenJui-Che TsaiDepartment of Biomedical Engineering, I-SHOU University, Kaohsiung County, TaiwanDepartment of Materials Engineering, Tatung University, Taipei, Taiwan Search for more papers by this author , Shyh Ming KuoDepartment of Biomedical Engineering, I-SHOU University, Kaohsiung County, TaiwanCorresponding author: Professor Shyh Ming Kuo, Department of Biomedical Engineering, I-SHOU University, Kaohsiung County, Taiwan. Search for more papers by this author , Shwu Jen ChangDepartment of Biomedical Engineering, I-SHOU University, Kaohsiung County, Taiwan Search for more papers by this author , Ioannis ManousakasDepartment of Biomedical Engineering, I-SHOU University, Kaohsiung County, Taiwan Search for more papers by this author , and Tim-Mo ChenPlastic and Restructive Department, Tri-Service Hospital, Taipei, Taiwan Search for more papers by this author https://doi.org/10.4015/S1016237207000306Cited by:3 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractThe surgical applications of platelet glue (a mixture of platelet gel and fibrin glue) are so far particularly prominent in plastic and orthopedic surgeries. It is shown to accelerate bone fracture and wound healing in many clinical practices. Over the years, one of the components used to prepare platelet glue (PG), thrombin, could only be obtained from pooled human plasma or bovine blood after repeated centrifugation processes. The quantity from this thrombin source is limited and its process deemed time consuming and the risk of infection does exist. Here, we present a stand alone device (TGD®, Thrombin Generation Device) which could prepare large quantities of human thrombin from autologous or single donor allogeneic plasma donations under sterile conditions. With this specific thrombin product, we could easily further mix with platelet and fibrinogen to prepare the platelet glue. PG not only contains various growth factors such as PDGF, TGF-β which are believed to be beneficial to wound healing but also increase the sticky strength in different operations. In this study, the reconstruction efficacy of PG combined with osteoconductive scaffold, biphasic calcium phosphate scaffold, for a post-operative calvarial bone defect was evaluated.Keywords:ThrombinPlatelet glueGrowth factorTGD® device References M. R. Jacksonet al., Blood Coagul. Fibrinolysis 7, 737 (1996). Crossref, ISI, Google ScholarM. Radosevich, H. A. Goubran and T. Burnouf, Vox Sang. 72, 133 (1997). Crossref, ISI, Google ScholarA. M. Scheuleet al., Gastrointestinal Endoscopy 48(1), 83 (1998). Crossref, ISI, Google ScholarH. Mitsuhataet al., Anesthesiology 81(4), 1074 (1994). Crossref, ISI, Google ScholarS. Bhanot and J. C. Alex, Facial Plast. Surg. 18, 27 (2002). Crossref, ISI, Google ScholarD. M. Green and B. Klink, Plastic & Reconstructive Surgery 101(4), 1161 (1998). Crossref, ISI, Google ScholarM. Franchiniet al., Orthopedics 28, 161 (2005). Crossref, ISI, Google ScholarG. Crovettiet al., Transfus. Apheresis Sci. 30, 145 (2004). Crossref, ISI, Google ScholarR. G. Willet al., Lancet 347, 921 (1996). Crossref, ISI, Google ScholarM. R. Scottet al., PNAS 96, 15137 (1999). Crossref, ISI, Google ScholarC. A. Llewelynet al., Lancet 363, 417 (2004). Crossref, ISI, Google ScholarM. Valbonesiet al., Int. J. Artif. Organs. 25, 334 (2002). Crossref, ISI, Google ScholarG. Gianniniet al., Transfus. Apheresis Sci. 30, 139 (2004). Crossref, ISI, Google Scholar Remember to check out the Most Cited Articles! Notable Biomedical TitlesAuthors from Harvard, Rutgers University, University College London and more! FiguresReferencesRelatedDetailsCited By 3CHITOSAN IN APPLICATIONS OF BIOMEDICAL DEVICESCheng-Wen Lan, Gregory Cheng-Chie Niu, Shwu Jen Chang, Chun-Hsu Yao, and Shyh Ming Kuo25 April 2012 | Biomedical Engineering: Applications, Basis and Communications, Vol. 23, No. 01EVALUATION OF CHITOSAN/CaSO4/PLATELET-RICH PLASMA MICROSPHERE COMPOSITES AS ALVEOLUS OSTEOGENESIS MATERIALShwu Jen Chang, Shyh Ming Kuo, Cheng-Wen Lan, Ioannis Manousakas, and Pei Hua Tsai25 April 2012 | Biomedical Engineering: Applications, Basis and Communications, Vol. 21, No. 02Evaluation of Bone Growth Using Artificial Bone Substitute (Osteoset®) and Platelet Gel Mixtures: A Preliminarily Study in DogsShyh Ming Kuo, Li-Chun Lin, Pei-Leun Kang, Jui-Che Tsai and Shwu Jen Chang11 July 2009 | Artificial Cells, Blood Substitutes, and Biotechnology, Vol. 37, No. 2 Recommended Vol. 19, No. 04 Metrics History Accepted 25 July 2007 KeywordsThrombinPlatelet glueGrowth factorTGD® devicePDF download