Abstract
Slow inward currents modulate neuronal firing patterns and may generate depolarizing afterpotentials (DAPS). We report a novel, slow Na + current (I NaS) in striatal and hippocampal neurons that can generate DAPS. I NaS activated at depolarizations greater than -40 mV, was tetrodotoxin insensitive, and activated and deactivated slowly over hundreds of milliseconds. I NaS was dependent upon extracellular Na +, but was not affected by 0 mM extracellular Ca 2+ or by Ca 2+ channel blockers (Mn 2+ Cd 2+, or Co 2+). A tetrodotoxin-insensitive, Na +-dependent plateau potential that was likely generated by I NaS was shown to underlie DAPS during intracellular recordings from hippocampal CA1 pyramidal neurons. Membrane depolarizations and DAPs generated by I NaS may contribute to alterations in neuronal firing and epileptiform bursting.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
