Abstract
A new testosterone 5α-reductase inhibitor, 8'9'-dehydroascochlorin, was isolated from the cultured mycelium of Verticillium sp. FO-2787. This compound (M.W. : 402, C23H27ClO4) consists of 5-chloroorcylic aldehyde and 2, 3, 4-trimethylcyclohexenone moieties, which are connected via a chain of (2E, 4E)-3-methyl-2, 4-pentadiene. The IC50 value of the new microbial metabolite for testosterone 5α-reductase activity prepared from rat prostate was 4×10-4M.
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