A novel systemic inflammation response index (SIRI) for predicting postoperative survival of patients with esophageal squamous cell carcinoma

Abstract

BackgroundInflammation is closely associated with the initiation and development of tumors. Based on the counts of peripheral neutrophils, monocytes and lymphocytes, we established a new systemic inflammation response index (SIRI) to predict postoperative survival of patients with esophageal squamous cell carcinoma (ESCC). MethodsA total of 916 ESCC patients treated with radical esophagectomy were enrolled in the present study. ResultsSurvival analysis indicated that the median overall survival (OS) in patients with SIRI≤1.2 was significantly higher than that in patients with SIRI>1.2. The nomogram including SIRI could more accurately predict OS compared with the TNM staging system. In addition, the changes of SIRI from baseline to 8 weeks after the operation were correlated with patient survival. The patients with an increase in SIRI >75% had worse OS compared with those with no change, while the patients with a decrease in SIRI >75% or in the scope of 25% ~75% exhibited better OS. ConclusionsSIRI was an independent prognostic index of ESCC patients after the radical resection. The nomogram integrating the SIRI could help clinicians to screen the high-risk patients and formulate the individualized treatment schemes.