Abstract
We report a facile, efficient, and environmentally benign approach for preparing morpholino-linked 1,4-dihydropyridine derivatives. The four-component fusion of morpholin-4-amine, diethyl acetylene dicarboxylate, malononitrile, and chosen substituted benzaldehydes occurred under microwave irradiation under mild conditions in the presence of potassium carbonate as a catalyst. This protocol offers remarkable benefits such as excellent yields (92–98 %), easy handling, simple workup, economy, cleaner reaction profile, green conditions, shorter reaction time (≤10 min), and avoiding column chromatography for purification.
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