Abstract
Panacis Japonici Rhizoma (Zhu-Jie-Shen in Chinese), the root of P. japonicus C.A. Mey., is commonly used in traditional Chinese Medicine. Saponins are the major bioactive compounds in this herb. The similarity of polarity and structure of the natural products in herb caused the difficulty of purification and resulted in the shortage and high cost of the reference compounds, which has greatly hindered efforts toward quantification in quality control. A novel strategy using a standardized reference fraction for qualification of the major saponins in Panacis Japonici Rhizoma was proposed to easily and effectively control the quality of PJR. The strategy is feasible and reliable, and the methodology of the developed approach is also validated. The standardized reference fraction was used for quantification, which might solve the shortage of the pure reference compounds in the quality control of herbal medicines.
Highlights
Most plants in the Panax genus have been used as traditional Chinese medicines for different medical purposes for a long time
Preliminary investigation found that the saponins in P. japonicus absorbed in in
The results of stability test shows the variation of analytes in solutions during the tested range is small (RSD ≤ 0.58%, Table 2), indicating that the sample and total P. japonicus saponin (TPJS) solutions were stable at room temperature (25 ◦ C) for 24 h
Summary
Most plants in the Panax genus have been used as traditional Chinese medicines for different medical purposes for a long time. The types and contents of ginsenosides vary greatly in different Panax species. Both GRR and PQR contain high contents of dammarane-type saponins, as well as certain amounts of oleanane-type saponins, which are used as medicinal tonic. PJR contains both dammarane and oleanane-type saponins, and the content of oleanane-type saponins is about ten times higher than that of dammarane-type saponins. Quantification of multiple ginsenosides is a rational strategy cardioprotective, andactivities neuroprotective activities [8,9,10]. Quantification of multiple ginsenosides is for qualitystrategy control for quality those herbs andfor their products [11,12,13,14].
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