Abstract
A novel solid-state polyvinylchloride (PVC) membrane potentiometric dopamine-selective microsensor was constructed based upon dopamine-imprinted polymer used as the ionophore in the membrane structure. The optimum membrane composition was determined as 4% (w/w) MIP, 69% (w/w) bis(2-ethylhexyl) sebacate (DOS), 26% (w/w) PVC, and 1% (w/w) potassiumtetrakis(4-chlorophenyl) borate (KTpClPB). The detection limit of the microsensor was determined to be 3.71×10-7 mol.L-1. The microsensor exhibited a super-Nernstian response for dopamine over the concentration range of 10-6-10-1 mol.L-1, with a short response time (<15 s) and a slope of 60.3±1.3 mV per decade (R2: 0.9998) over seven weeks. The microsensor was effectively performed in a pH range of 4.0-8.0 and a temperature range of 5-30 °C. The microsensor has been successfully demonstrated for the rapid, accurate, selective and reproducible determination of dopamine in pharmaceutical formulations with the recovery of 104.3-104.8%. The obtained results were in good harmony with the UV-Vis results at a confidence level of 95%.
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