Abstract
The research of proteomics is becoming one of important tasks in biological medical research after genomics. The first step to perform the protein analysis is to analyze gel electrophoresis images. In this paper, a novel scheme for registration of 2D gel electrophoresis images is proposed. First, we move one 2DE image along the x-axis and y-axis directions, overlap it on the second 2DE image and then calculate the mutual information of these two images. Repeat this procedure, we can find out the best registration result when the maximum mutual information is achieved. Next, the spot detection process is accomplished by using fuzzy c-means for segmentation and region growing for spot size calculation. At last, linear tracking technique is employed for spot matching. From the experimental results, it is observed that the performance of the proposed system is superior to the common used registration software Image Master System.
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