Abstract

To quickly and efficiently recognize abnormal patterns from large-scale time series and pathological signals in epilepsy, this paper presents here a preliminary RSW&TST framework for Multiple Change-Points (MCPs) detection based on the Random Slide Window (RSW) and Trigeminal Search Tree (TST) methods. To avoid the remaining local optima, the proposed framework applies a random strategy for selecting the size of each slide window from a predefined collection, in terms of data feature and experimental knowledge. For each data segment to be diagnosed in a current slide window, an optimal path towards a potential change point is detected by TST methods from the top root to leaf nodes with O(log3(N)). Then, the resulting MCPs vector is assembled by means of TST-based single CP detection on data segments within each of the slide windows. In our experiments, the RSW&TST framework was tested by using large-scale synthetic time series, and then its performance was evaluated by comparing it with existing binary search tree (BST), Kolmogorov-Smirnov (KS)-statistics, and T-test under the fixed slide window (FSW) approach, as well as the integrated method of wild binary segmentation and CUSUM test (WBS&CUSUM). The simulation results indicate that our RSW&TST is both more efficient and effective, with a higher hit rate, shorter computing time, and lower missed, error and redundancy rates. When the proposed RSW&TST framework is executed for MCPs detection on pathological ECG (electrocardiogram)/EEG (electroencephalogram) recordings of people in epileptic states, the abnormal patterns are roughly recognized in terms of the number and position of the resultant MCPs. Furthermore, the severity of epilepsy is roughly analyzed based on the strength and period of signal fluctuations among multiple change points in the stage of a sudden epileptic attack. The purpose of our RSW&TST framework is to provide an encouraging platform for abnormal pattern recognition through MCPs detection on large-scale time series quickly and efficiently.

Highlights

  • Epilepsy is a common chronic neurological disorder, and all epilepsies involve episodic abnormal electrical activity in the brain

  • When our Random Slide Window (RSW)&Trigeminal Search Tree (TST) was applied for Multiple Change-Points (MCPs) detection on different pathological signals in the clinical databases on PhysioNet [1,5,31], the abnormal patterns were recognized in terms of the data features among resultant MCPs within abnormal data segments of epilepsy patients

  • A series of time series samples were synthesized with different numbers of target MCPs ranging from 30 to 120, the proposed RSW&TST framework was tested by comparing it to binary search tree (BST), KS and T methods, respectively

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Summary

Introduction

Epilepsy is a common chronic neurological disorder, and all epilepsies involve episodic abnormal electrical activity in the brain. Epilepsies, called seizures, may be associated with cardiac arrhythmias, prominent arterial oxygen desaturations, and sudden death [1]. The authors reported that postictal heart rate oscillations are marked by the appearance of transient but prominent heart rate oscillations in a group of patients with partial epilepsy (PE). This finding may be a marker of neuroautonomic instability, and may imply some association between perturbations of the heart rate and partial seizures [1,2]. The identification of recurrent, transient perturbations of pathological signals in brain activity during sleep, so called cyclic alternating patterns (CAP), is of significant interest as they have been linked to multiple pathologies [3,5]

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