A novel Roll Porous Scaffold 3D bioprinting technology

Abstract

Biomanufacturing is a novel promising technology and an important field of research, offering hope for bridging the gap between organs shortage and transplantation needs. The paper describes the ways to overcome the main technological barriers and to accelerate biofabrication of 3D cellular tissue constructs greatly, to build multi-cell implantations of high density and accuracy for vascular system. It should be noted that though the Roll Porous Scaffold (RPS) 3D is a novel technology and never being used but derived from the time-proved bioprinting methods and components. The potential of the RPS are micron and submicron precision, performance of up to 5 l per hour with 20 μm layer thickness, which makes it more applicable than traditional methods. Features of the RPS are based on employing the Archimedean spiral and manufacturing 3D objects layer-by-layer with their transformation into a support ribbon. RPS may be one of the possible ways to solve the serious problem of “3D bioprinting” for tissue engineering and regenerative medicine in the nearest future.