Abstract
The third gasotransmitter hydrogen sulfide (H2S) plays a vital role to human health and diseases. A water-soluble ratiometric fluorescent probe (HS-1) for hydrogen sulfide (H2S) has been developed, which resulted in an increase of the emission at 403 nm along with a concomitant decrease of fluorescence peak at 519 nm, the ratios of emission intensities at 403 and 519 nm (I403/I519) displayed an increase from 0.27 to 8.54. This probe showed excellent selectivity toward H2S over other common anions and biothiols. Furthermore, these successes of intracellular imaging experiments in A549 cells indicated that this probe is suitable for imaging of ex-/endogenous hydrogen sulfide in living cells.
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