Abstract

It is challengeable for traditional electrochemical sensors to determine EDCs in food samples due to inadequate reproducibility. Herein, a novel ratiometric electrochemical sensor for monitoring two typical EDCs referred to 17β-estradiol (E2) and bisphenol S (BPS) was developed. Electrodeposition method was utilized for facile decoration of Au nanoparticles (AuNPs) on MIL-101(Fe) to obtain AuNPs@MIL-101(Fe) composite as sensing material. In contrast to common ratiometric approaches, the Fe signal supplied by MIL-101(Fe) was expediently and innovatively adopted as the internal reference tag instead of fixing electroactive molecules. Furthermore, benefited from the synergistic effect of MIL-101(Fe) and AuNPs, AuNPs@MIL-101(Fe) composite exhibited remarkably enhanced electrochemical activity, resulting in strengthened Fe reference signal and facilitated oxidation process of EDCs. With the rise of EDCs’ concentration, the current response of EDCs gradually increased while the Fe signal almost kept constant. Thus, a new ratiometric electrochemical sensor was successfully developed with a wide linear range of 0.039–7.80 µM for EDCs as well as low LOD of 9.8 nM for E2 and 11.2 nM for BPS. Finally, the newly constructed sensor was achieved in evaluating the two targets in milk samples. The developed sensor exhibited high reproducibility, stability, sensitivity and practicability, providing a new idea for constructing ratiometric electrochemical sensors and a new method for EDCs detection.

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