Abstract

Purpose/Objective: Radiogenic therapy is a novel approach to treat cancer. It implies using genetic modification to alter sensitivity of tumor or normal tissue to the effect of radiation. Using recombinant adenovirus (Ad) as a vector, heterologous gene delivery with consequent phenotypic change in radiosensitivity has been shown with different therapeutic payloads. Radiation inducible promoters incorporated into Ad vectors have been used to deliver therapeutic genes. However, lack of tumor specificity and moderate levels of gene induction have been a concern. On the other hand, tissue specific promoters (TSP) have been widely developed and show both high selectivity and robust gene expression in transfected tumors. Of note, radiation also induces gene expression by transcriptional regulation of some of these promoters. Herein we hypothesize that radiotherapy may enhance the selectivity and level of expression of TSP.

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