Abstract
BackgroundThis study aimed to evaluate the feasibility, safety, and value of a quick technique for transendoscopic enteral tubing (TET) through mid-gut.MethodsA prospective interventional study was performed in a single center. A TET tube was inserted into mid-gut through the nasal orifice and fixed on the pylorus wall by one tiny titanium endoscopic clip under anesthesia. The feasibility, safety, success rate, and satisfaction with TET placement were evaluated for enteral nutrition or fecal microbiota transplantation.ResultsA total of 86 patients underwent mid-gut TET. The success rate of the TET procedure was 98.8% (85/86). Mean tubing time of the TET procedure was 4.2 ± 1.9 min. 10 cases of procedure was enough for training of general endoscopist to shorten the procedure time (7.0 min vs 4.0 min, p < 0.05). 97.7% (84/86) of patients were satisfied with the TET placement. Procedure-related and tube-related adverse events were observed in 8.1% (7/86) and 7.0% (6/86) of patients respectively. There were no moderate to severe adverse events during tube extubation.ConclusionsTET through mid-gut is a novel, convenient, reliable and safe procedure for mid-gut administration with a high degree of patient satisfaction.Trial registrationThis research was retrospectively registered with clinicaltrials.gov. Trial registration date: 29th November 2017. Trial registration number: NCT03335982.
Highlights
This study aimed to evaluate the feasibility, safety, and value of a quick technique for transendoscopic enteral tubing (TET) through mid-gut
Clinical studies have shown that fecal microbiota transplantation (FMT) has a therapeutic role in clostridium difficile infection (CDI), inflammatory bowel diseases (IBD), refractory constipation, chronic diarrhea, liver diseases and metabolic syndrome [1,2,3]
This study aimed to evaluate the feasibility, safety, and value of the mid-gut TET technique
Summary
This study aimed to evaluate the feasibility, safety, and value of a quick technique for transendoscopic enteral tubing (TET) through mid-gut. Fecal microbiota transplantation (FMT) has gained appeal as a therapeutic option worldwide. FMT via colonoscopy is a classic approach, but in our previous study on ulcerativecolitis [4], those patients have difficulty to maintain the infused microbiota suspension for enough time through this way. We designed the colonic transendoscopic enteral tubing (TET) technology, which made whole-colon administration of treatment and repeat FMTs possible [5]. Some patients are resistant to undergo bowel preparation for colonoscopy or some are not suitable for colonic delivering way. Mid-gut delivering way is an important option for those patients. In our previous researches on FMT for Crohn’s disease [6, 7], patients and physician faced the similar problem that some patients need repeat FMT during hospitalization, and some may need enteral nutrition at the same time
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