Abstract
BackgroundC5L2, a G protein-coupled receptor (GPCR), has been demonstrated to be a ligand for acylation-stimulating protein (ASP). The aim of the present study is to evaluate the association of a novel variation (901A > G) of C5L2 gene with coronary artery disease (CAD).MethodsWe identified a novel single nucleotide polymorphism (SNP), (901G > A), in exon 2 using a polymerase chain reaction direct-sequencing method. This nucleotide change causes the amino-acid order from Arginine to glutaminate at codon 300. We analyzed the relationship between this SNP and CAD in two independent case–control studies: one was in a Han population (492 CAD patients and 577 control subjects) and the other was in a Uygur population (319 CAD patients and 554 control subjects).ResultsThe frequency of AG genotype in CAD subjects was less than that in the control subjects not only in Han (1.8% vs 8.6%, P < 0.001, OR = 0.143, 95% CI: 0.068 ~ 0.302) but also in Uygur population (0.9% vs 5.2%, P = 0.001, OR = 0.246, 95% CI: 0.072 ~ 0.837). After adjustment for known CAD risk factors such as hypertension, diabetes, smoking, age and gender, the difference remained significant.ConclusionThe 901G > A polymorphism of C5L2 may be a genetic maker of CAD in the Han and Uygur population in western China.
Highlights
C5L2, a G protein-coupled receptor (GPCR), has been demonstrated to be a ligand for acylationstimulating protein (ASP)
In Han subjects, the following variables were significantly different between the two groups: diabetes; smoking; drinking; the serum concentration of glucose; Total cholesterol (TC); High-density lipoprotein (HDL-C); Low-density lipoprotein (LDL-C) and creatinine
There was no significant difference in the following variables between coronary artery disease (CAD) patients and control subjects: Hypertation; serum concentration of TG; BUN; the body mass index (BMI); age; and sex
Summary
C5L2, a G protein-coupled receptor (GPCR), has been demonstrated to be a ligand for acylationstimulating protein (ASP). In China, the prevalence of obesity and type 2 diabetes mellitus (T2DM), which is important risk factor for atherosclerosis and CAD [8,9,10], is increasing rapidly. C5L2 is a potential ligand for both C5a (a powerful inflammatory factor) and ASP It added one addition association between the adipose and the immune system. Activation of C5L2 initiates protein kinase C activation and translocation and glucose transporter translocation [14,15,16]. This resulting in a net accumulation of adipose TG stores
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