Abstract
Background Cancer metastasis is the most common cause of death in cancer patients. Although surgical resection remains the only potentially curative treatment for lung cancer, lung cancer patients after curative surgery still have high risk of cancer recurrence. If we can perform any prophylactic strategy during the perioperative period for cancer recurrence, surgical outcome for lung cancer could be improved significantly. Atrial natriuretic peptide (ANP) has been used clinically for the treatment with heart failure in Japan, and exhibits a wide range of biological activities including beneficial effects on cardiovascular system through binding the guanylate cyclase-A (GC-A) receptor. We previously reported that ANP administration during the perioperative period had a prophylactic effect on postoperative cardiopulmonary complications in lung cancer patients. We performed the follow-up survey in these patients, and found that the incidence of cancer recurrence after curative surgery for lung cancer was significantly lower in the ANP-treated patients compared to the control patients (surgery alone). The objective of the present study was to investigate the mechanism of ANP in the prevention of cancer metastasis.
Highlights
Cancer metastasis is the most common cause of death in cancer patients
We previously reported that Atrial natriuretic peptide (ANP) administration during the perioperative period had a prophylactic effect on postoperative cardiopulmonary complications in lung cancer patients
In this hematogenous metastasis model, administration of ANP notably inhibited metastasis in the lung compared to the control mice (13±3 vs. 119±13, P
Summary
Cancer metastasis is the most common cause of death in cancer patients. Surgical resection remains the only potentially curative treatment for lung cancer, lung cancer patients after curative surgery still have high risk of cancer recurrence. If we can perform any prophylactic strategy during the perioperative period for cancer recurrence, surgical outcome for lung cancer could be improved significantly. We previously reported that ANP administration during the perioperative period had a prophylactic effect on postoperative cardiopulmonary complications in lung cancer patients. We performed the follow-up survey in these patients, and found that the incidence of cancer recurrence after curative surgery for lung cancer was significantly lower in the ANP-treated patients compared to the control patients (surgery alone). The objective of the present study was to investigate the mechanism of ANP in the prevention of cancer metastasis
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