A novel peroxidase mimetic Co-MOF enhanced luminol chemiluminescence and its application in glucose sensing

Abstract

In this work, a metal organic framework material ([Co(L)(H2O)2]n, Co-MOF) was synthesized by a facile hydrothermal method, and it was found that Co-MOF have a peroxidase-like activity. They can efficiently catalyze the chemiluminescence (CL) reaction between luminol and H2O2 and enhance the CL signal significantly. The possible enhancement mechanism suggested that Co-MOF catalyzed the decomposition of H2O2 into O2 and increased the generation of •O2−. Based on these findings, a new highly sensitive glucose sensor was constructed combined with the luminol-H2O2-Co-MOF CL system and glucose oxidase. Under the optimal conditions, the method exhibited a good linear response to glucose in the range of 0.04˜8 μM with a detection limit of 1 × 10-8 M. The method has been further applied in the quantitative determination of glucose in human serum and urine successfully.