Abstract
Scorpion venoms are rich in ion channel modulator peptides toxins. Proteomic analysis of soluble venom of the Colombian scorpion Centruroides margaritatus revealed that it contains mainly peptides with molecular weights ranging between 2.5-8 kDa. Among them, a novel short peptide (named Cm28) consists of 27 amino acids with MW of 2820 Da inhibited voltage-gated potassium channels Kv1.2 and Kv1.3 with Kd value of 0.96 and 1.3 nM, respectively. There was no significant shift in the conductance-voltage (G-V) relationship for both channels in the presence of toxin.
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