A Novel Parameter-Less Clustering Method for Mining Gene Expression Data

Abstract

Clustering analysis has been applied in a wide variety of fields. In recent years, it has even become a valuable and useful technique for in-silico analysis of microarray or gene expression data. Although a number of clustering methods have been proposed, they are confronted with difficulties in the requirements of automation, high quality, and high efficiency at the same time. In this paper, we explore the issue of integration between clustering methods and validation techniques. We propose a novel, parameter-less, and efficient clustering algorithm, namely CST, which is suitable for analysis of gene expression data. Through experimental evaluation, CST is shown to outperform other clustering methods substantially in terms of clustering quality, efficiency, and automation under various types of datasets.