Abstract
Bone morphogenetic proteins (BMPs) have played a central role in the development of regenerative therapies for bone reconstruction. However, the high cost and side effect profile of BMPs limits their broad application. Oxysterols are a promising alternative to BMPs. We studied the impact of Oxy133, a novel oxysterol analogue, on the in vitro and in vivo osteogenic differentiation of rabbit bone marrow stromal cells (BMSCs) and the mechanisms by which it mediates its effects.
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