Abstract
A simple, efficient on-off fluorescent probe 7-(diethylamino)-N'-(8-methyl-9- (naphthalen-1-yl)-9H-purin-6-yl)-2-oxo-2H-chromene-3-carbohydrazide (CMP) based on coumarin and purine derivatives has been rotationally designed, synthesized and characterized. Interestingly, the novel fluorescent probe CMP exhibited a highly sensitive, selective and quick response (within 1 min) to Co2+ in HEPES buffer solution (pH 7.4), and with a low detection limit (0.487 μM). Notably, visual color change was observed with the addition of Co2+ to the probe CMP, its color changed from yellow to pink. Moreover, the binding stoichiometry of CMP with Co2+ was determined to be 1:1 by Job’s plot and MS spectra analysis, and the binding mechanism of them was further demonstrate by density functional theory (DFT) study. This novel probe CMP provided a new method for rapid and naked-eye recognition of Co2+ with a cheap and easy-to-make process, high efficiency and stable storage.
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