A Novel of L-Serine/Chitosan Electrochemical Sensor for Determination of Paracetamol

Abstract

A novel type of L-serine and chitosan modified glassy carbon electrode (L-Ser/CS-GCE) as a electrochemical sensor for determination of paracetamol was fabricated. With potassium ferricyanide as the probe, electrochemical properties of this sensor were characterized via electrochemical impedance spectroscopy(EIS) and measured EIS data were fitted with an equivalent circuit to investigate the detailed information about the electrode/solution interface. The electrochemical behavior of paracetamol on L-Ser/CS-GCE was studied via Cyclic voltammetry(CV). This electrochemical sensor showed an excellent electrocatalytic activity for the oxidation of paracetamol in pH4.9 acetate buffer solution and accelerated electron transfer between the electrode and paracetamol. Linear scan voltammetry (LSV) was used for determination of paracetamol. Peak current increased linearly with increasing paracetamol concentration in the range of 2.0×10-6～1.0×10 -3mol/L and the detection limit was found to be 8.3×10-7mol/L. The electrochemical sensor showed good stability and reproducibility. The practical application of the electrochemical sensor was successfully applied for determining the concentration of paracetamol in commercial acetaminophen tablets.