Abstract
A novel controlled drug delivery micro-device was successfully prepared with biodegradable implants based on PLGA by solvent evaporation method. The micro-chambers were fabricated using the UV-LIGA technology. The controlled release process resulted from the design of the micro-chambers and the characteristics of biodegradable polymers. Implant bioactivity was tested using in vitro and in vivo release. The implants kept good shape and cisplatin was homogeneous loaded in the PLGA implants. The precast implants appeared hexagon. With different proportion of PLA and PGA segment, the swelling behavior and the hydrolytic degradation rate of implants became lower due to the increase of PLA hydrophobic segment. In vitro and in vivo drug release behavior was studied using cisplatin as model drug, the implants could control the diffusion of cisplatin. The results demonstrated that this type of controlled drug delivery micro-device could be more potential application in tumor therapy.
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