A Novel Nutritional Approach to Prevent Parenteral Nutrition–Associated Cholestasis in Two Premature Infants with Short Bowel Syndrome

Abstract

Infusion of soybean oil-based Intralipid is a major risk factor for parenteral nutrition (PN)–associated cholestasis that often occurs in infants treated with prolonged PN for short bowel syndrome. Parenteral fish oil–based lipid emulsion (Omegaven) has been reported to treat this condition, but it is not readily available in the United States and still requires a central venous catheter for administration. Enteral administration of Microlipid has been shown to decrease ostomy output and facilitate weight gain in infants with enterostomies. We describe 2 premature infants with short bowel syndrome who received early supplementation with enteral Microlipid and fish oil after bowel resection, and became independent of PN without cholestasis.