Abstract
The three-component synthesis of 2,4,5-trisubstituted imidazoles, a typical acid-catalyzed reaction, could be conducted successfully with good to excellent yields in a neutral ionic liquid, 1-methyl-3-heptyl-imidazolium tetrafluoroborate ([HeMIM]BF 4), under solvent-free and microwave-assisted conditions. The combined merits of microwave irradiation and ionic liquid make the three-component condensation with safe operation, low pollution, rapid access to products and simple workup.
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