Abstract
Abstract Cysteine (Cys) plays key roles in various pathological and physiological processes. Thus, the specific detection of Cys is a great necessity for the related disease diagnosis. Herein, we present a novel fluorescent probe based on a 2-benzothiazolyl-6-quinazolinyl-4-methylphenol moiety as fluorophore and a 2,4-dinitrobenzenesulfonyl moiety as detection functioned group. The probe presented a rapid and specific turn on response to Cys under physiological conditions, which could be convenient observed by the naked eyes. The detection mechanism was elucidated by HRMS, UV/vis absorption, fluorescence and DFT calculation. Furthermore, the probe was applied to monitor the endogenous Cys in living cells and mice.
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