Abstract
Objective: The present paper describes the development and evaluation of a Novel Finasteride (FSD) nanogel topical delivery for the treatment of Androgenetic Alopecia. Nano-based topical formulation was chosen to enhance the solubility, permeability, biocompatibility of drug and to overcome the problems associated with the oral delivery of finasteride.
 Methods: Various trails batches were prepared by using probe sonication method. Based on stability studies and particle size, NP4 trail was optimized which exhibited a spherical shape with a mean diameter of 113.80±0.72, the polydispersity of 0.28±0.01, zeta potential of-25.2 mV, drug entrapment efficiency of 92.67±0.47 %, and drug loading of 6.15±0.02 %. Storage stability studies demonstrated that the particle size and entrapment efficiency were not changed during 3 mo both at 4 °C and room temperature. Finasteride (FSD) NLCs were characterized for particle size by scanning electron microscope (SEM), chemical state by X-Ray diffraction (XRD), physical stability by centrifugation and thermodynamic stability by Freeze-thaw method. These prepared nanoparticles were transformed into topical nanogel and further evaluated.
 Results: Among the different trails, C2 trail of NLC gel has shown excellent gelling capacity, clear appearance, good viscosity characteristics and was selected for further evaluation studies. Batches of topical nanogel were characterized through pH, homogeneity, spreadability, viscosity, drug content and in vitro drug release study. Based on pH (6.5-6.8), drug content (91.25±0.9%), spreadability (6.7 cm/sec), C2 batch was subjected to In vitro skin occlusivity study, in-vitro release study and In vitro heamolysis study.
 Conclusion: The percent cumulative drug release for Finasteride (FSD) gel was found to be 758.52±1.49 µg at 24 h which is quite higher than plain gel and Finasteride (FSD) gel showed maximum occlusiveness and excellent spreadability and found to be stable. In conclusion, prepared Finasteride (FSD) Nanogel could be used with promising potential for the treatment of Androgenetic Alopecia.
Highlights
Androgenetic alopecia (AGA) is a common chronic, dermatological condition in both men and women characterized by a hereditary inheritance pattern, beginning with the advent of puberty where scalp hair progressively thins in a defined pattern in the temporal region, progressive miniaturization of the hair follicle and shaft
The present study aims for the preparation and evaluation of FSD-loaded nanoparticles formula and incorporation of the same into gel for the treatment of androgenetic alopecia
The results suggest that there was no significant difference in values of Entrapment efficiency, drug content and physical characteristics of formulation remained unchanged suggesting that formulation was stable under given conditions
Summary
Androgenetic alopecia (AGA) is a common chronic, dermatological condition in both men and women characterized by a hereditary inheritance pattern, beginning with the advent of puberty where scalp hair progressively thins in a defined pattern in the temporal region, progressive miniaturization of the hair follicle and shaft. Androgenetic alopecia is an extremely common dermatological disorder affecting both men and women This disease is characterized by a reduction of frontal hair in temporal region, resulting in a gradual decrease in the hair diameter [1]. There is a drawback in using water-alcohol solutions, as only a fraction of the applied drug dose reaches the target site, it shows low permeability through the keratin layer. As a result, those products do not meet the expectations of consumer, due to lack of adherence to treatment and the drawbacks of utilizing conventional liposomes in transdermal delivery, as they are trapped in the upper skin layers, have been previously reported [5]. Studied in vitro drug release by dialysis membrane, skin occlusivity test and hemolysis test
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
