Abstract
Mycolactones are polyketide macrolide toxins produced by the emerging human pathogen Mycobacterium ulcerans, the causative agent of the destructive skin disease Buruli ulcer.1, 2 Mycolactone appears to be the primary virulence determinant for the infection,2 and purified mycolactone has potent cytotoxic, apoptotic and immunomodulatory properties.2–4
Highlights
Mycolactones are polyketide macrolide toxins produced by the emerging human pathogen Mycobacterium ulcerans, the causative agent of the destructive skin disease Buruli ulcer.[1,2] Mycolactone appears to be the primary virulence determinant for the infection,[2] and purified mycolactone has potent cytotoxic, apoptotic and immunomodulatory properties.[2,3,4]
We report that when Cyp140A7 was expressed in the recently discovered fish pathogen Mycobacterium marinum DL045, a novel mycolactone was produced from the engineered strain
We first examined the structure of the mycolactones normally produced by several recently discovered Mycobacterium ulcerans-like mycobacteria isolated from diseased fish.[14,17]
Summary
Mycolactones are polyketide macrolide toxins produced by the emerging human pathogen Mycobacterium ulcerans, the causative agent of the destructive skin disease Buruli ulcer.[1,2] Mycolactone appears to be the primary virulence determinant for the infection,[2] and purified mycolactone has potent cytotoxic, apoptotic and immunomodulatory properties.[2,3,4]. Australian strains of M. ulcerans, whose virulence plasmid lacks MUP_053, typically produce mycolactone C, in which the C12’ hydroxy group is missing.[16] We wished to test whether Cyp140A7 might oxidise an alternative
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
