Abstract
The kidney is the primary organ regulating serum urate levels. It is responsible for ∼70% of total body urate excretion. Defective handling of urate by the kidney is a frequent cause of hyperuricemia and gout. Impaired intestinal excretion can also contribute to hyperuricemia.1 The molecular mechanisms of urate metabolism in humans have been difficult to study because of species differences and lack of appropriate model organisms mimicking human physiology and pathophysiology.
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