Abstract
Monoclonal antibodies to specific families of TCR variable domains serve as highly useful immunochemical tools for basic research in T-cell biology and diagnosis of autoimmune diseases. Monoclonal antibody MEM-262 characterized in this communication recognizes β chains of the TCR expressed by HPB-ALL cell line (carrying V β5.3) and a small subset of peripheral blood T cells. This subset is larger than that recognized by a previously described V β5.3-specific mAb. MEM-262 potently stimulates selective expansion of the T-cell subset, efficiently immunoisolates native TCR complexes as well as free β chains and uniquely recognizes denatured TCRβ chains under the conditions of Western blotting.
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