A novel modified graphite paste sensor based on porous Sn-1,4-benzenedicarboxylate metal–organic frameworks for stripping voltammetric detection of 5-fluorouracil drug

Abstract

A novel modified graphite paste sensor based on Sn-1,4-benzene dicarboxylic (Sn-BDC) metal–organic framework (MOF) has been prepared for the stripping voltammetric detection of 5-fluorouracil (5-FU; anticancer drug). The Sn-BDC MOF was synthesized via the solvothermal method and characterized through Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and Brunauer–Emmett–Teller surface area method (BET). The formed MOF has a good crystallinity accompanied with a specific surface area of 710 m2.g−1, which provides an increment in the reaction sites, improving the performance of the sensor. 1.0 % Sn-BDC modified graphite paste sensor (MGPS) exhibited the best electroactive surface area (1.31 cm2) and electrocatalytic activity (ΔEp) (0.16 V) with the lowest resistivity (Rst = 230 Ω). Under the optimum accumulation parameters, the MGPS achieved the limit of detection to be 0.03 and 0.06 nM with a wide calibration linearity range of 0.1–5.0 and 0.3–7.0 nM for the detection of the anticancer drug 5-fluorouracil (5-FU) in bulk and urine fluid, respectively. In addition, MGPS exhibited satisfactory sensitivity (2.683 μA·nM−1), reproducibility and suitable storage stability, along with anti-interference ability, during the detection of 5-FU in biological fluid.