Abstract
As an important endogenous signaling molecule, SO2 plays a key role in many physiological processes. However, excessive intake of SO2 and its derivatives lead to serious health complications of various diseases. In order to study the role of SO2 and its derivatives in the biological environment, it is of great significance to develop new and effective monitoring methods. Here, a new red emission fluorescent probe (TNPI) based on pyrazoline and hemicyanine dyes for the high selective detection of SO2 derivatives was developed. The probe TNPI showed some advantages such as long emission wavelength (640 nm), obvious color and fluorescence changes after reaction with SO2 derivatives, high selectivity and sensitivity toward SO2 derivatives (detection limit = 80 nM), and large fluorescence emission shift (160 nm) and signal ratio change (from 0.45–445, about 989 times). Intriguingly, the probe was successfully exploited for the fluorescence imaging of SO2 derivatives in the mitochondria of living cells with low cytotoxicity.
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