Abstract

Due to its inherent sensitivity to both subtle changes in crystal structure and the hydrogen bonding network of organic molecular crystals and moisture, terahertz time-domain spectroscopy (THz-TDS) is a very promising technique to study physico-chemical changes during stability testing of pharmaceutical dosage forms. Using a variable temperature and humidity chamber the effects of moisture and temperature can be studied in the tablet formulation in situ by terahertz spectroscopy.

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