Abstract
Next generation sequencing (NGS) has the ability to detect ratios of normal:abnormal cells in blastocyst biopsies. With the current biopsy methodology clumps of 4-6 cells are analyzed together and a 50:50 mixture of monosomic:trisomic cells would be reported as a normal embryo. However, scoring a single clump of cells cannot reliably identify the true degree of mosaicism in trophectoderm samples [1]. The purpose of this study was to dissect single-cells from human blastocyst biopsies and to prove that it is possible to successfully carry out NGS analysis.
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