A novel method for fabrication of biodegradable scaffolds with high compression moduli.

Abstract

It has been previously shown that, when used for meniscal reconstruction, porous copoly(L-lactide/epsilon-caprolactone) implants enhanced healing of meniscal lesions owing to their excellent adhesive properties. However, it appeared that the materials had an insufficient compression modulus to accomplish 100% fibrocartilage formation. In addition, to be used for meniscal prosthesis, the compression modulus of the porous materials should be larger than 150 kPa in order to protect the articular cartilage. A technique was developed to prepare stiff porous materials of a high molecular weight 50/50 copoly(L-lactide/epsilon-caprolactone) suitable for fibrocartilage regeneration in meniscal implants and meniscal prosthesis. Porous microspheres (50-250 microm) were agglutinated in the presence of NaCl crystals (250-300 microm). The microspheres were mixed with solid solvent in order to obtain a homogeneous distribution of solvent over the spheres. By changing the amount of solvent and crystals, the density and the compression modulus could be varied over a range of 0.07 g ml(-1) to 0.5 g dl(-1) and 40-1100 kPa, respectively.