A Novel Method for Evaluating the Cardiotoxicity of Traditional Chinese Medicine Compatibility by Using Support Vector Machine Model Combined with Metabonomics

Yubo Li,Haonan Zhou,Zhiguo Hou,Jiabin Xie,Yanjun Zhang,Mayassa Salum Ally,Yanyan Xu

doi:10.1155/2016/6012761

Abstract

Traditional biochemical and histopathological tests have been used to evaluate the safety of traditional Chinese medicine (TCM) compatibility for a long time. But these methods lack high sensitivity and specificity. In the previous study, we have found ten biomarkers related to cardiotoxicity and established a support vector machine (SVM) prediction model. Results showed a good sensitivity and specificity. Therefore, in this study, we used SVM model combined with metabonomics UPLC/Q-TOF-MS technology to build a rapid and sensitivity and specificity method to predict the cardiotoxicity of TCM compatibility. This study firstly applied SVM model to the prediction of cardiotoxicity in TCM compatibility containing Aconiti Lateralis Radix Praeparata and further identified whether the cardiotoxicity increased after Aconiti Lateralis Radix Praeparata combined with other TCM. This study provides a new idea for studying the evaluation of the cardiotoxicity caused by compatibility of TCM.

Highlights

In the early research, Li et al have found 10 highly specific early cardiac toxicity biomarkers and established a support vector machine (SVM) prediction model [1]
Creatine kinase (CK) and lactate dehydrogenase (LDH) were selected as biochemical indices to evaluate whether the drug caused damage to the heart [18,19,20,21,22]
We can see that creatine kinase (CK) and LDH were significantly increased in heishunpian group compared with the control group

Summary

Introduction

Li et al have found 10 highly specific early cardiac toxicity biomarkers and established a support vector machine (SVM) prediction model [1]. They used the SVM model to predict the cardiotoxicity of drugs and traditional Chinese medicine (TCM); results showed that the SVM prediction model had a better sensitivity and specificity. Currently there is no effective method for evaluating the cardiotoxicity of TCM compatibility. Aconiti Lateralis Radix Praeparata (fuzi in Chinese) is one of the commonly traditional Chinese medicines used in clinical treatment; modern research has shown that fuzi has lots of efficacy, such as cardiotonic, anti-inflammatory, analgesic, antimyocardial ischemia, and hypoxia effect. Other studies have found that, for fuzi and Rhei Radix Et Rhizoma

Methods

Results

Conclusion