Abstract
Cold atmospheric plasmas (CAPs) used in plasma medicine have shown great potential in various aspects including wound healing, dermatology, cancer therapy, etc. It is one of the important issues to determine the plasma dosage in plasma medicine because it dominates the specific plasma treatment results. However, the multi-process interactions between CAPs and biological materials make it rather challenging to give an accurate and versatile definition for plasma dosage. In this study, the ratio of the discharge energy to the number of the treated in vitro kidney cells (mJ/cell) was employed as the unit of the plasma dosage. Additionally, inspired by basic knowledge of pharmacy, the median lethal dose (LD50) was employed to help estimate the plasma dosage. The experimental results show that the value of LD50 using the newly designed CAP Bio-Med Platform for the kidney cells is 34.67 mJ/cell. This biology-based method has the advantages of easy operation, independence of specific CAP sources, and also independence of complex interactions between CAPs and the treated biological targets, and consequently, may provide a new direction to quantitatively define the plasma dosage in various plasma medical applications.
Highlights
Plasma medicine [1] is one of the most widely concerned interdisciplinary fields of cold atmospheric plasmas (CAPs) owing to its great potential in clinical treatment
Disinfection [3] to wound healing [4,5], skin disease treatment [6], and even cancer therapy [7]. These results show that the CAP treatment can be more effective than the traditional method for certain diseases with few side effects
The CAP sources used in plasma medicine are operated at atmospheric pressure and have gas temperatures close to room temperature, making it feasible and convenient to be applied for the treatment of biological materials such as living tissues, cells, etc
Summary
Plasma medicine [1] is one of the most widely concerned interdisciplinary fields of cold atmospheric plasmas (CAPs) owing to its great potential in clinical treatment. Disinfection [3] to wound healing [4,5], skin disease treatment [6], and even cancer therapy [7]. These results show that the CAP treatment can be more effective than the traditional method for certain diseases with few side effects. The generation and transport characteristics of the RONS largely depend on the CAP sources and the ambient conditions. The CAP sources used in plasma medicine are operated at atmospheric pressure and have gas temperatures close to room temperature, making it feasible and convenient to be applied for the treatment of biological materials such as
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