A novel method for determination of inorganic oxyanions by electrospray ionization mass spectrometry using dehydration reactions.

Abstract

Novel methods for the determination of inorganic oxyanions by electrospray (ES) ionization mass spectrometry have been developed using dehydration reactions between oxyanions and carboxylic acids at the ES interface. Twelve oxyanions (VO3 −, CrO4 2−, MoO4 2−, WO4 2−, BO3 3−, SiO3 2−, SiO4 4−, AsO4 4−, AsO2 −, SeO4 2−, SeO3 2− and NO2 −), out of 16 tested, reacted with at least one of four aminopolycarboxylic acids, i.e. iminodiacetic acid (IDA), nitrilotriacetic acid (NTA), trans‐1,2‐diaminocyclohexane‐N,N,N′,N′‐tetraacetic acid and triethylenetetramine‐N,N,N′,N″,N′″,N′″‐hexaacetic acid, at the ES interface to produce the dehydration products that gave intense mass ion responses, sufficient for trace analysis. As examples, trace determinations of CrVI and silica in water samples were achieved after online ion exchange chromatography, where the dehydration product of CrO4 2− and NTA (m/z 290) and that of SiO4 4− and IDA (m/z 192) were measured. The limits of detection of the respective methods were 17 nM (0.83 ng Cr/ml) for CrVI and 0.17 μM (4.8 ng Si/mL) for SiO4 4−. Copyright © 2016 John Wiley & Sons, Ltd.