Abstract
A novel metabolic pathway for creatinine, degradation of creatinine to glycine via N-methylhydantoin, N-carbamoylsarcosine and sarcosine in turn, was found to operate in Pseudomonas putida 77. N-Methylhydantoin, sarcosine and glycine were detected as metabolites from creatinine, and enzyme activities responsible for the degradation of creatinine, N-methylhydantoin, N-carbamoylsarcosine and sarcosine were observed in a crude cell extract, while neither creatinine amidohydrolase activity nor creatine were detected at all. It is suggested that creatinine was utilized as a source of both carbon and nitrogen at the same time, and that N-methylhydantoin was also utilized efficiently.
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